Correspondence BIEIsOUNAL 385 From this it seemed that the relative concentrations of uric acid and o-tolidine might be important. By increasing the concentration of o-tolidine to five times that present in the original reagent2 (and using acetate instead of phosphate buffer) a plasma-uric-acid level of 10 mg. per 100 ml. has been found not to interfere, and a level of 20 mg. per 100 ml. to produce only a 2% underestimation. With this modified reagent, therefore, the trueglucose concentration

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... blood can now be estimated simply and accurately with the automatic analyser, as in the original manual method. It seems likely that similar modification of the reagents used in other published methods will produce the same results.-I am, etc.,