in coordination with the Research Infrastructure for Minority Institutions (RIMI) Program, presents… Genomic views of transcriptional and post-transcriptional gene regulation

Vishy Iyer
Diversity in gene expression between different cellular states is often generated at the level of RNA, and is regulated by transcription factors, chromatin structure, and post-transcriptional regulation by miRNAs. Diversity in gene regulation between individuals is also driven in part by genetic variants, which may be termed allele-specific regulation. This talk will give an overview of our studies on genome-wide regulation in three domains. First, we examine the role of chromatin remodelers
more » ... matin remodelers and a histone variant using yeast as a model system. I then describe a gene regulatory network involving transcription factors and miRNAs that mediates human cell proliferation responses. Finally I describe how we can identify allele-specific transcription factor binding and quantitative trait loci (QTLs) that underlie variation in transcription factor binding and chromatin structure in humans.