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Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum
Microbial Cell Factories
Ganoderic acids (GAs), derived from the medicinal mushroom Ganoderma lucidum, possess anticancer and other important pharmacological activities. To improve production of GAs, a homologous farnesyl diphosphate synthase (FPS) gene was overexpressed in G. lucidum. Moreover, the influence of FPS gene overexpression on GA production was investigated by developing the corresponding mathematical models. Results: The maximum levels of total GAs and individual GAs (GA-T, GA-S, and GA-Me) in thedoi:10.1186/s12934-019-1164-3 fatcat:t2xzyrw3lbbo3dwsbqe443abwm