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Exploring the effect of aminoglycoside guanidinylation on ligands for Tau exon 10 splicing regulatory element RNA
Organic and biomolecular chemistry
We describe the effect of guanidinylation of the aminoglycoside moiety on acridine-neamine-containing ligands in the stem-loop structure located at the exon 10-5'intron junction of Tau pre-mRNA, an important regulatory element of tau gene alternative splicing. On the basis of dynamic combinatorial chemistry experiments, ligands that combine guanidinoneamine and two different acridines were synthesized and their RNA-binding properties were compared with those of their amino precursors.doi:10.1039/c2ob26623g pmid:23108673 fatcat:4nqnhps3qrgynnoz3jiq2kerwu