Expression genomics in breast cancer research: microarrays at the crossroads of biology and medicine

Lance D Miller, Edison T Liu
2007 Breast Cancer Research  
Genome-wide expression microarray studies have revealed that the biological and clinical heterogeneity of breast cancer can be partly explained by information embedded within a complex but ordered transcriptional architecture. Comprising this architecture are gene expression networks, or signatures, reflecting biochemical and behavioral properties of tumors that might be harnessed to improve disease subtyping, patient prognosis and prediction of therapeutic response. Emerging
more » ... strategies that incorporate knowledge of pathways and other biological phenomena in the signature discovery process are linking prognosis and therapy prediction with transcriptional readouts of tumorigenic mechanisms that better inform therapeutic options. ABC = activated B cell; CGH = comparative genomic hybridization; DLBCL = diffuse large-B-cell lymphoma; ER = estrogen receptor; GCB = germinal-center B cell; NF = nuclear factor; pCR = complete pathologic response; PI3-kinase = phosphoinositide 3-kinase; SNP = singlenucleotide polymorphism; T/FAC = paclitaxel, 5-fluorouracil, adriamycin and cyclophosphamide).
doi:10.1186/bcr1662 pmid:17397520 pmcid:PMC1868923 fatcat:jvzoro26afeclj5cpa2jmaex74