Autosomal dominant neovascular inflammatory vitreoretinopathy — a review

Małgorzata A. Kowalczyk, Robert Rejdak
2019 Ophthalmology Journal  
Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a hereditary autoimmune disorder of the eye caused by mutations in the CAPN5 gene. It is characterized by non-specific uveitis in the anterior chamber and vitreous leading to panuveitis, iris and retinal neovascularization, cystoid macular edema, abnormal retinal pigmentation, vitreous hemorrhage, intraocular fibrosis, membrane formation and tractional retinal detachment. ADNIV is a progressive disease leading to complete
more » ... lindness despite of treatment. Confirmation is made by genetic analysis demonstrating mutations of the CAPN5 gene.
doi:10.5603/oj.2019.0002 fatcat:kqixcuunmjgwvhgrhnlexalp7y