Synthesis of 3-Hexyl-4-cyan-6,7-dimethoxy Isocoumarin

2014 Asian Journal of Chemistry  
trihydroxy-3-methyl-isocoumarin, which was isolated from Flaveria bidentis (L) Kuntze, had herbicidal activity and its structure was modified in this research in order to get the isocoumarin compouds with higher herbicidal activity. The reaction starts with 2-amino-4,5-dimethoxy benzoate and then diazo iodination, esterfication, heck coupling, cyclization reaction and cyna substitution reaction were tested to obtain 3-hexyl-4-cyan-6,7-dimethoxy isocoumarin. The isocoumarin derivative is an
more » ... priate precursor for the synthesis of new herbicide.
doi:10.14233/ajchem.2014.16703 fatcat:dbeoa7efe5fyvahm4rzn525gcu