Case Report Breast nodular fasciitis with abundant spindle cells and osteoclast-like giant cells mimicking inflammatory myofibroblastic tumor

Lu-Jian Wang, Qing-Fu Zhang, Ai-Lin Jin, Xue-Shan Qiu, Li-Mei Sun
2016 Int J Clin Exp Pathol   unpublished
Nodular fasciitis is a relatively common lesion usually presenting in soft tissues. The occurrence in the breast is exceptional rare. Histologically, this tumor is characterized by plump spindle cells arranged in short fasci-cles. Occasionally, osteoclast-like giant cells may be present. Herein, we present a case of breast nodular fasciitis in a 46-year-old Chinese female. The tumor was predominantly composed of abundant spindle cells with light to moderate atypia and scattered osteoclast-like
more » ... iant cells and lymphocytes reminiscent of inflammatory myofibroblastic tumor. The unusual histological appearance can pose a great diagnostic challenge. It may be easily misdiagnosed, especially if the specimen is limited or from fine-needle aspiration.