Cyclic Heptapeptides, Cordyheptapeptides C–E, from the Marine-Derived Fungus Acremonium persicinum SCSIO 115 and Their Cytotoxic Activities

Ziming Chen, Yongxiang Song, Yuchan Chen, Hongbo Huang, Weimin Zhang, Jianhua Ju
2012 Journal of natural products  
Three new cycloheptapeptides, cordyheptapeptides C−E (1−3), were isolated from the fermentation extract of the marine-derived fungus Acremonium persicinum SCSIO 115. Their planar structures were elucidated on the basis of extensive MS, as well as 1D and 2D (COSY, HMQC, and HMBC) NMR spectroscopic data analyses. The absolute configurations of the amino acid residues were determined by single-crystal X-ray diffraction, Marfey's method, and chiralphase HPLC analysis. Compounds 1 and 3 displayed
more » ... otoxicity against SF-268, MCF-7, and NCI-H460 tumor cell lines with IC 50 values ranging from 2.5 to 12.1 μM.
doi:10.1021/np300152d pmid:22642609 fatcat:okhan6j75rayngljvgrh7f5naa