Health-Related Quality of Life in Children With Congenital Hyperinsulinism

Jonna M. E. Männistö, Jarmo Jääskeläinen, Hanna Huopio
2019 Frontiers in Endocrinology  
Quality of life (QoL) has not been studied in patients with congenital hyperinsulinism (CHI). Objectives: To examine whether the health-related quality of life (HRQoL) is worsened in patients with persistent or transient CHI. Methods: We studied HRQoL of 65 children with CHI aged 3-17 years (60% males) recruited from the nationwide CHI registry. The median ages were 9.6 (range 3.5-16.3) and 7.4 (3.1-17.9) years in persistent (P-CHI, n = 33) and transient (T-CHI, n = 32) CHI groups,
more » ... roups, respectively. HRQoL was examined by generic KINDL-R questionnaire and the scores were compared to the age-and gender-specific reference values. Results: In self-reports of subjects aged 11-17 years and in parent reports of children aged 3-17 years, P-CHI or T-CHI children did not have statistically lower scores in any of the six dimensions (physical well-being, emotional well-being, self-esteem, family, friends, and school) or in total scores compared to the reference values. Conclusions: CHI is not associated with low HRQoL in childhood or adolescence.
doi:10.3389/fendo.2019.00670 fatcat:saygsa5lzvdd7abbu4c2mh7wcy