BACKGROUND: Osteopetrosis is a collective term used for a pathological condition with defective function of osteoclasts presented with range of sclerosing bone diseases along with skeletal, renal, haematological & neurological manifestation. It may be autosomal recessive (ARO), autosomal dominant (ADO) and X-linked. It presents with hydrocephalus, short stature and anaemia, involvement of ocular nerve or facial nerve. Hypocalcemia, tetany, seizures & secondary hypoparathyroidism is known to

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... r. CASE REPORT: Two patients of osteopetrosis were posted for orthopaedic surgery. Both patients were operated under combined spinal epidural anaesthesia. 2ml of 0.5%Bupivacaine+30mcg clonidine was given intrathecally & epidural supplementation was given with Bupivacaine 3 cc increments after two segment regression of sensory level. Postoperative analgesia was provided by epidural Bupivacaine 0.125% along with Inj. Tramadol 50 mg on patient's request. CONCLUSION: Even if administration of anesthesia is a challenge in patients of Osteopetrosis, regional anaesthesia can be given safely with proper preoperative preparation & intraoperative care.