Generation of integration-free induced pluripotent stem cells from healthy individuals

Cristine Marie Yde Ohki, Leoni Grossmann, Christian Döring, Per Hoffmann, Stefan Herms, Anna Maria Werling, Susanne Walitza, Edna Grünblatt
2021 Stem Cell Research  
Ten human induced pluripotent stem cell (iPSC) lines have been derived from five healthy controls matched to a study including Attention-Deficit Hyperactivity Disorder patients (ADHD). Both female and male children and adolescents aged 6-18 years were recruited. Isolated keratinocyte cells from the participants were reprogrammed into iPSCs using non-integrating Sendai virus to deliver the reprogramming factors Oct3/4, Sox2, Klf4 and cMyc.
doi:10.1016/j.scr.2021.102269 pmid:33667761 fatcat:iweowqouffegpkwjf5wjjj56w4