Treatment of Ringworm with Griseofulvin

Yoshisada Takahashi, Shin'ya Takahashi, Norimi Inaki
1960
Griseofulvin is a metabolic product of Penicillium griseofulvum DrnRCKX isolated by OxFORD, RAISTRICK and S1MONART 1 ) in 1939. Its antifungal activity was recognized since early time, and it was chiefly used in the agricultural field. In was also found that griseofulvin displayed a systemic antifungal activity when it was applied as a preventive drug for Botrytis infection of lettus and Alternaria disease of tomato. In 1958, GENTLEs 2 l noticed that griseofulvin has a distinct therapeutic
more » ... t when it 1s given orally, 60 mg/kg per day consecutively, to guinea pigs infected experimentally with Microsporum canis. About that time, LAUDER and O'SuLLIVAN 3 ) obtained a similar result in cattle infected naturally with Trichophyton rubrum. Since that, griseofulvin became abruptly the object of dermatologists' attention as a therapeutic for trichophytoses. WILLIAMS, MARTEN and SARKANEY 4 ) firstly in 1958 treated human ringworm patients. with griseofulvin. According to their report, 7 cases of ringworm due to Trichophyton rubrum were cured within 2~3 •weeks by the consecutive oral administration of griseofulvin, 2.0 g daily. The effectiveness of oral griseofulvin in human patients was also proved by RIEHL 5 l, and BLANK and Rorn 6 l. The present authors have tested the clinical effect of griseofulvin in the treatment of ringworm. The results are described in the present paper.
doi:10.11554/antibioticsa.13.3_192 fatcat:yxeyy4dppff35p5wi5oroc36oa