An existing way to produce glucose uses enzymes to hydrolyzepolysaccharides. Aspergillusniger is recognized to produce glucoamylases capable to reduce starch to glucose molecules, used in fermentations processes as substrate. For continuous bioreactors operation mode, the substrate feed is required during bioprocess. Thus, enzymatic reactors able to continuously produce substrate feed are extremely necessary. Although, control strategies are demanded to regulate the variables of enzymatic

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... s for adequate fermentation feed. For this reason, the paper analyses control strategies to regulate glucose concentration in the reactor outlet flow and reaction media volume, manipulating starch and enzymatic inlet solutions flows and reactors outlet flow. Control loop was designed analyzing processes variables responses to disturbances in the manipulated variables. Ratio control was implemented and the results demonstrate its superiority to SISOglucose concentration control.