Public health surveys in recent years have demonstrated a burden of diseases caused due to oxidative stress and inflammation. Disease caused by oxidative stress has been observed to be cured by using natural chelators. This paper describes various chelators and their properties in treating multiple diseases. Literature for this review article was collected from different sources, to capture as many relevant references as could reasonably be expected, an extensive variety of medical, Ecological,

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... environment and scientific databases were looked to distinguish essential Investigations. Moreover, different web engines were hunt down site pages that may give references. The aim of this review article is to evaluate and highlight the importance of natural chelators identified and their importance in prevention of diseases as it is one of the most neglected approach in medical practice. Relevant research article of the last fifteen years were Reviewed especially from PubMed but some article up to twenty years were also included for Having interesting content. A higher therapeutic index of natural chelators has been accounted with treating different neurodegenerative diseases, skin diseases and multiple stages of cancers. Additional clinical research is needed to be done to make results more clear, physiological and molecular alterations of diseases are needed to be evaluated in order to select an appropriate chelator and extraction from various fruits and vegetables are needed to be done to get an expertise on these diseases.