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An important research application of amyloid imaging with positron emission tomography (PET) is detection of the earliest evidence of fibrillar amyloid-beta (Aβ) deposition. Use of amyloid PET for this purpose, requires a reproducible method for defining a cutoff that separates individuals with no significant Aβ deposition from those in which Aβ deposition has begun. We previously reported the iterative outlier approach (IO) for the analysis of Pittsburgh Compound-B (PiB) PET data. Developmentsdoi:10.1016/j.neuroimage.2013.01.015 pmid:23353602 pmcid:PMC3605888 fatcat:d5pnduryyzfyjmt2sxoqskdtvm