Effect of Turmeric Oil in Reproductive Efficiency of Immature Female Rats Exposed to Oxidative Stress Induced by Potassium Dichromate
IOSR Journal of Pharmacy and Biological Sciences
This study carried out to understand the effects of Potassium Dichromate (K 2 Cr 2 O 7 ) and Turmeric Oil (TO) on reproductive efficiency. Twenty four weanling immature female albino rats aged 22 day divided randomly into 4 groups (6 rats in each group). 1 st group received 0.1 ml dimethyle sulfoxide (DMSO) 5% solution as a control (I/P for 14 day), 2 nd group received K 2 Cr 2 O 7 dissolved in distilled water (0.4 mg/kg, I/P, for 14 day), 3 rd group received TO dissolved in 5% DMSO solution
... 5% DMSO solution (20 mg/kg, I/P, for 14 day), 4 th group received both K 2 Cr 2 O 7 +TO (0.4 mg/kg, I/P +20 mg/kg, I/P, ½ h in between, for 14 day). Rats treated with K 2 Cr 2 O 7 show significant increase in Malondialdehyde (MDA) level and significant decreases in uterine and ovarian weights, serum Glutathione (GSH) level, percentage of vaginal opening time and diameter of ovarian follicles in categories (101-200), (201-300) and (>400), while those treated with TO show significant increase in uterine and ovarian weights, percentage of vaginal opening time, serum GSH, and diameter of ovarian follicles in categories (1-100) and (>400), with significant decrease in MDA level, moreover treatment with K 2 Cr 2 O 7 and TO together show significant increase in uterine and ovarian weights, percentage of vaginal time opening, serum GHS level and diameter of ovarian follicles in categories (201-300) and (>400), with significant decrease in MDA level. In conclusion, K 2 Cr 2 O 7 has bad effects on reproductive efficiency of female rats and TO have improvement on some of these effects.