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Motivation: A k-point mutant of a given RNA sequence s = s 1 , . . . , sn is an RNA sequence s = s 1 , . . . , s n obtained by mutating exactly k-positions in s; i.e. Hamming distance between s and s equals k. To understand the effect of pointwise mutation in RNA (Schuster et al., 1994; Clote et al., 2005b) , we consider the distribution of energies of all secondary structures of k-point mutants of a given RNA sequence. Results: Here we describe a novel algorithm to compute the mean anddoi:10.1093/bioinformatics/bti669 pmid:16159920 fatcat:wcmk3cgyhvejlpnzhwhxbc5wzu