Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel Plasticizer

S. Simar-Mentières, F. Nesslany, M.-L. Sola, S. Mortier, J.-M. Raimbault, F. Gondelle, L. Chabot, P. Pandard, D. Wils, A. Chentouf, Zongming Ren
2021 Journal of Toxicology  
Phthalate esters, mainly di-ethylhexylphthalate (DEHP), represent a class of chemicals primarily used as plasticizers for polyvinyl chloride in a wide range of domestic and industrial applications. These phthalate esters are low-toxicity environmental contaminants. To address these drawbacks, POLYSORB® ID 37, a blend of diesters obtained from esterification of isosorbide with plant-based fatty acids, was developed. The company can now offer PVC manufacturers a new product which competes with
more » ... halates and other such chemicals. The market for plasticizers is very important, and ROQUETTE intends to provide a more sustainable and safer product. Isosorbide diester is bio-based (made from glucose and vegetable fatty acids). This plasticizer is registered in REACH regulation for high volumes (>1000 T/year). Risk assessment was obtained by conducting a wide range of biodegradability and toxicological protocols, using rodent models, according to established guidelines. Overall, all of the toxicological and biodegradability studies demonstrated that POLYSORB® ID 37 is nontoxic to mammalian life and is readily biodegradable.
doi:10.1155/2021/9970896 fatcat:5n4efxyspjc5nlmnzkc7vottfq