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We describe a new method to automatically discriminate between patients with Alzheimer's disease (AD) or mild cognitive impairment (MCI) and elderly controls, based on multidimensional classification of hippocampal shape features. This approach uses spherical harmonics (SPHARM) coefficients to model the shape of the hippocampi, which are segmented from magnetic resonance images (MRI) using a fully automatic method that we previously developed. SPHARM coefficients are used as features in adoi:10.1016/j.neuroimage.2009.05.036 pmid:19463957 pmcid:PMC3001345 fatcat:zjnkg67iibb3zltb4vkfjkomjy