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Bioinformatics of alternative splicing and its regulation
2006
Briefings in Bioinformatics
The sequencing of the human genome and ensuing wave of data generation have brought new light upon the extent and importance of alternative splicing as an RNA regulatory mechanism. Alternative splicing could potentially explain the complexity of protein repertoire during evolution, and defects in the splicing mechanism are responsible for diseases as complex as cancer. Among the challenges that rise in light of these discoveries are cataloguing splice variation in the human and other eukaryotic
doi:10.1093/bib/bbk005
pmid:16761365
fatcat:m3y6dxczujblnasvypznhww72i