A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf
.
GCN4 Enhances the Stability of the Pore Domain of Potassium Channel KcsA
2009
Biophysical Journal
KcsA, a prokaryotic potassium channel, is the first channel that has a known crystal structure of the transmembrane domain. The crystal structure of its soluble C-terminal domain, however, still remains elusive. Biophysical and electrophysiological studies have previously implicated the essential roles of the C-terminal domain in pH sensing and in vivo channel assembly. We examined this functional assignment by replacing the C-terminal domain with an artificial tetramerization domain, GCN4-LI.
doi:10.1016/j.bpj.2008.12.1660
fatcat:y2bhzlqbnfhz5cumupx2iqr3eu