Harnessing the Potential of Multiomics Studies for Precision Medicine in Infectious Disease

Rebecca A Ward, Nima Aghaeepour, Roby P Bhattacharyya, Clary B Clish, Brice Gaudillière, Nir Hacohen, Michael K Mansour, Philip A Mudd, Shravani Pasupneti, Rachel M Presti, Eugene P Rhee, Pritha Sen (+6 others)
2021 Open Forum Infectious Diseases  
The field of infectious diseases currently takes a reactive approach, treating infections as they present in patients. Although certain populations are known to be at greater risk of developing infection (e.g., immunocompromised), we lack a systems approach to define the true risk of future infection for a patient. Guided by impressive gains in -omics technologies, future strategies to infectious diseases should take a precision approach to infection through identification of patients at
more » ... diate and high-risk of infection and deploy targeted preventative measures (i.e., prophylaxis). The advances of high-throughput immune profiling by multiomics approaches (i.e., transcriptomics, epigenomics, metabolomics, proteomics) holds the promise to identify patients at increased risk of infection and enable risk-stratifying approaches to be applied in the clinic. Integration of patient-specific data using machine learning improves the effectiveness of prediction, providing the necessary technologies needed to propel the field of infectious diseases medicine into the era of personalized medicine.
doi:10.1093/ofid/ofab483 pmid:34805429 pmcid:PMC8598922 fatcat:7u6z7eud6rgljnnngpuijjgqwm