Structure and actions of insulin-like growth factor binding protein-2 (IGFBP-2)

Slater TA, Ali N, Patel PA
2018 Medical Research and Innovations  
The insulin-like growth factor (IGF) system consists of growth factors, receptors and binding proteins, and overlaps significantly with insulin signalling pathways. IGF-1 and IGF-2 are essential for growth and development and have also been shown to play a key role in insulin sensitivity, obesity, endothelial dysfunction, angiogenesis and tumorigenesis. They are tightly regulated by a family of six binding proteins (IGFBP) which form complexes with IGF, with only 1% of IGF free in the
more » ... ee in the circulation. Despite this apparently predominantly inhibitory role, IGFBPs have been shown to have a variety of effects on cell growth, proliferation, angiogenesis and metabolism, with both IGF dependent and independent effects observed. IGFBP-2 in particular has been shown in several studies to be linked to tumour metastasis and poorer outcomes in cancer, and has been shown to promote tube formation, proliferation, migration and angiogenesis in vitro, through a variety of pathways. Higher circulating levels of IGFBP-2 have also been shown to protect against obesity and improve insulin sensitivity. In this brief review we will look at some of these actions in more detail, and describe a potential future role for IGFBP-2 incorporation in cell based therapies. Slater TA (2018) Structure and actions of insulin-like growth factor binding protein-2 (IGFBP-2) Volume 2(3): 2-3
doi:10.15761/mri.1000144 fatcat:fnfmfpeykbbqdo3iq6ugyszrfe