Several studies showed that obesity and fat deposition in the tissues along with inflammatory response may induce insulin resistance and finally type II diabetes. Salsalate can inhibit IKK and NF-KB inflammatory pathway. The aim of this study was to determine the efficacy of salsalate as an anti-inflammatory drug in blood glucose decrement of diabetics. Methods: This was a double blind case-control trial. Sixty newly diagnosed diabetic patients were randomized in the drug and the placebo

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... . The drug group used were received 3g Salsalate per day (two 750 mg tablets every 12 hours orally) for one month. Findings: At baseline there was no significant differences between drug group mean fasting plasma glucose level (124 mg/dl) and placebo group (127 mg/dl) (P = 0.628). Twenty eight patients in drug group and 23 ones in placebo group finished the study. Salsalate had reduced significantly the fasting glucose in the drug group (20 mg/dl) in comparison to placebo group (P < 0.05). Conclusion:This study showed that using 3 grams of Salsalate for one month reduces 15.5% of baseline blood glucose level of diabetic cases. These acceptable results may open a new approach in the treatment of diabetes. Key words:Diabetes, Inflammation, Salcylates, Salsalate.