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Viral Protein R Regulates Docking of the HIV-1 Preintegration Complex to the Nuclear Pore Complex
1998
Journal of Biological Chemistry
Replication of human immunodeficiency virus type 1 (HIV-1) in non-dividing cells depends critically on import of the viral preintegration complex into the nucleus. Recent evidence suggests that viral protein R (Vpr) plays a key regulatory role in this process by binding to karyopherin ␣, a cellular receptor for nuclear localization signals, and increasing its affinity for the nuclear localization signals. An in vitro binding assay was used to investigate the role of Vpr in docking of the HIV-1
doi:10.1074/jbc.273.21.13347
pmid:9582382
fatcat:iycxnjyfbvfifkxnkyccv5qzre