Directed Motion of Proteins along Tethered Polyelectrolytes

Katja Henzler, Sabine Rosenfeldt, Alexander Wittemann, Ludger Harnau, Stephanie Finet, Theyencheri Narayanan, Matthias Ballauff
2008 Physical Review Letters  
We present the first time-resolved investigation of motions of proteins in densely grafted layers of spherical polyelectrolyte brushes. Using small-angle x-ray scattering combined with rapid stopped-flow mixing, we followed the uptake of bovine serum albumin by poly(acrylic acid) layer with high spatial and temporal resolution. We find that the total amount of adsorbed protein scales with time as t 1=4 . This subdiffusive behavior is explained on the basis of directed motion of the protein
more » ... of the protein along the polyelectrolyte chains.
doi:10.1103/physrevlett.100.158301 pmid:18518159 fatcat:jmtkqofx5bawzderzzeulylpge