Obstructive sleep apnea syndrome (OSAS) is a common sleeprelated breathing disorder OSAS is associated with diurnal symptoms such as excessive daytime sleepiness and cognitive deficits. Several cognitive functions may be altered in OSAS such as attention, memory, executive cognitive control and motor coordination. P300 is a neurophysiological correlate of selective attention, novelty detection and working memory. Deterioration of mental fatigue in patients with OSAS, directly correlated to the

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... everity of nocturnal disorder breathing; however, supports the hypothesis that long-term Nasal continuous positive airway pressure (CPAP) therapy significantly improves sleepiness and mental fatigue. Objectives: We seek to explore the effect of using CPAP on OSAS patient's attention and short term memory by measuring auditory P300 after three months of its regular use. Materials and methods: P300 and AHI before and after the regular use of CPAP were done. Results and conclusions: The severity of OSAS decreased and the parameters of P300 improved toward better results, but, not reaching the normal average. Finally, we concluded that the CPAP regular use in OSAS improves not only sleepiness but also it improves their cognitive ability.