Uterine Reactivity During The Estrous Cycle Phase of Experimentally-Induced Hyperurecemic Rats
Bulletin of Egyptian Society for Physiological Sciences
Hyperuricemia is considered as an important risk factor of miscarriage and prematurity. This study aims to demonstrate if there is a direct effect of hyperuricemia on the spontaneous uterine contractions or uterine reactivity. Hyperuricemia was induced by 4 weeks of daily intraperitoneal (i.p.) injection of oxonic acid potassium salt (250mg/kg) in a group of 10 rats. Another group (10 rats) received oxonic acid potassium salt and allopurinol (150 mg/L drinking water) daily for 4 weeks. A
... r 4 weeks. A control group (10 rats) was injected daily by 0.9% saline solution i.p. for 4 weeks. At the end of the experiment, systolic blood pressure was measured and serum uric acid (UA), serum urea, serum creatinine, serum malondialdehyde (MDA) and erythrocyte superoxide dismutase (SOD) activity were estimated. The uterine horns were taken for recording their reactivity to oxytocin and Ach. The data showed that hyperuricemia significantly increased serum UA, plasma MDA and systolic blood pressure and significantly decrease SOD activity, but insignificantly changed serum urea and creatinine and unexpectedly insignificantly changed the spontaneous uterine contractions and uterine reactivity to either of acetylcholine or oxytocin. Allopurinol treatment significantly decreased serum UA, plasma MDA and systolic blood pressure but insignificantly changed serum urea & creatinine, SOD activity, spontaneous uterine contractions and the uterine reactivity to either of Ach or oxytocin. Keywords Uterine reactivity Hyperuricemia Estrous cycle Oxonic acid Rats Bull. of Egyp. Soc. Physiol. Sci.