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The E2A (TCF3) gene reveals a dominant role during lymphocyte and CNS growth. E2A is an object of the E proteins family of TFs. E proteins encoded by bHLH TFs are a key moderator of B & T cells development. Precisely, sequencing of E proteins and antagonists reveals lymphoid development. The B & T cells lineage commitment suggested E2A, HEB, E2-2, ID2/ID3, and other bHLH TFs are necessary at a proximate phase of cellular maturation. E protein controls the responsibility of various factors anddoi:10.21203/rs.3.rs-1535370/v1 fatcat:q6p3b464bvc5pj5daqnhm44jca