A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf
.
Robust coordination of collective oscillatory signaling requires single-cell excitability and fold-change detection
[article]
2021
bioRxiv
pre-print
Complex multicellular behaviors are coordinated at the level of biochemical signaling networks, yet how this decentralized control mechanism enables robust coordination in variable environments and over many orders of magnitude of spatiotemporal scales remains an open question. A stunning example of these behaviors is found in the microbe Dictyostelium discoideum, which uses the small molecule cyclic AMP (cAMP) to drive the propagation of collective signaling oscillations and spatial waves
doi:10.1101/2021.09.02.457527
fatcat:okcwdwhxyfhffbvlwdj5scz7hy