The present research work describes the synthesis of new heterocyclic compounds. The 2-Hydrazino benzoxazole pre-prepared was reacted with sodium nitrite and CuCN and afford the 2-cyano amine benzoxazole(1).Compound(1) react with sodium azide and ammonium chloride in DMF afford the 1-H-tetrazole-5-amino benzoxazole(2) ,ethyl chloroacetate react with compound (2) to give ethyl -2-(5-benzoxazol-2-ylamine)-1H-tetrazol-1-yl) acetate compound (3).Treatment (3)with thiourea or urea afforded compounds

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... (4,5),p-bromo phenacyl bromide react with compounds (4,5) afforded (6,7),treatment (3) with hydrazine hydrate to afforded 2-(5benzoxazol-2-ylamino)1-H-tetrazol-1yl) acetohydrazide compound (8) . Azomethines (9, 10) were prepared through reaction of compound (8) with aromatic aldehyde, then (9,10) converted to thaizolidinone derivatives (11,12) after treatment with HSCH 2 COOH . Reaction of compound (8) with phenyl iso thiocyanate and ethyl chloro acetate afforded compounds (13, 14) respectively. All compounds were confirmed by their melting point, FT-IR spectrum, 1 HNMR spectrum for some them.