RNA secondary structures and their prediction

Michael Zuker, David Sankoff
1984 Bulletin of Mathematical Biology  
This is a review of past and present attempts to predict the secondary structure of ribonucleic acids (RNAs) through mathematical and computer methods. Related areas covering classification, enumeration and graphical representations of structures are also covered. Various general prediction techniques are discussed, especially the use of thermodynamic criteria to construct an optimal structure. The emphasis in this approach is on the use of dynamic programming algorithms to minimize free
more » ... One such algorithm is introduced which comprises existing ones as special cases. Definition of Structure. We number the bases of an RNA sequence from RNA SECONDARY STRUCTURES 593 M. ZUKER AND D. SANKOFF
doi:10.1007/bf02459506 fatcat:vbxit4zofjarbccwar44e4lkma