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Physical methods for enhancing drug absorption from the gastrointestinal tract
2021
Advanced Drug Delivery Reviews
Overcoming the gastrointestinal (GI) barriers is a formidable challenge in the oral delivery of active macromolecules such as peptide and protein based drugs. In the past four decades, a plethora of formulation strategies ranging from permeation enhancers, nanosized carriers, and chemical modification of the drug's structure has been investigated to increase the oral absorption of these macromolecular compounds. However, only limited successes have been achieved so far, with the bioavailability
doi:10.1016/j.addr.2021.05.024
pmid:34052229
fatcat:6r6tawagnrfu5euc365zu2hcta