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Embryonic Lethal Abnormal Vision-Like RNA-Binding Proteins Regulate Neurite Outgrowth and Tau Expression in PC12 Cells
1999
Journal of Neuroscience
Preserved Fulltext
The embryonic lethal abnormal vision (ELAV)-like proteins are mRNA-binding proteins that regulate mRNA stability. The neuronal members of this family are required for neuronal differentiation. We identified the binding region of purified HuD protein to a target neuronal mRNA encoding for the tau microtubuleassociated protein and demonstrated an in vivo interaction between the ELAV-like protein and its target tau mRNA. We show that treatment of neuronal cells with antisense
doi:10.1523/jneurosci.19-16-06907.1999
pmid:10436048
fatcat:pu5d5rjhi5dbzdbvbcirnw2yxu