Pulmonary Response to Polyurethane Dust

Klaus L. Stemmer, Eula Bingham, William Barkley
1975 Environmental Health Perspectives  
Weanling and 9 months or older rats were exposed to particles of an aged (PUF I) or freshly prepared (PUF II) rigid polyurethane foam by intratracheal intubation. The dose was 5 mg of particles. The response of the lung tissue was examined morphologically by serial sacrifices. Inflammation and macrophage activity were the initial responses. Fibrosis developed after 6 months. Nodular scars and perifocal emphysema were seen after 12 months. Four rats had a papillary adenoma in a major bronchus
more » ... a major bronchus after 18 months exposure to PUF II.
doi:10.2307/3428332 fatcat:wh22wsrfm5fhtmpc2ehcofzbji