Role of Pentoxifylline and Pulse Steroid Therapy in Managing Covid 19 Patients in a Tertiary Care Hospital in India: An Observational Study

Rishav Mukherjee
2020 figshare.com  
This hospital based observational study was done to evaluate the role of pentoxifylline and single dose pulse steroid in Covid 19 patients, where the patients were categorized according to the severity of the disease and their demographics and their association with co-morbidities. Pentoxifylline is a methyl-xanthine derivative and has been seen to have many properties like hemorheological effects, immune modulation,and inhibitory effects on TNF Alpha.(1) Pulse steroid on the other hand can
more » ... nuate the overall inflammatory response in the body.OBJECTIVES:● Studying the Covid 19 patients in relation to their demographic data, co-morbidity associations, and severity of the disease process.● Observing the role of pentoxifylline in all patients and the effectiveness of a pulse steroid in moderate to severe patients,on the basis of final outcome in terms of death, discharge or transfer to CCU facilities, duration of stay in a tertiary care centre.METHODS: Hospital based cross sectional study conducted among 60 RT-PCR confirmed Covid 19 afflicted patients, from 15th July to 10th August, 2020 were taken into the study,and classified into disease categories, at admission as per MOHFW, Government of India guidelines.2 Moderate & Severe Category patients were administered Pentoxifylline and Single Dose pulse steroid along with standard therapy.RESULTS: After adding these two drugs in the patients of this study along with standard therapy, the mortality rate observed was less compared to the national rate and the duration of hospitalization was shortened to 12 days, and less number of transfers to critical care units was observed among moderate- severe category patients.CONCLUSION: Pentoxifylline and Pulse steroid therapy due to its antiviral, anti-inflammatory, anti-oxidative, immune-modulatory, bronchodilator and respiratory supportive effects offers a protective role in Covid 19 case managemen
doi:10.6084/m9.figshare.13172630.v1 fatcat:m7a53bjfdbabnl3re2ulwvqd5a