Mood or affective disorder is psychological manifestations, depression is now known as a complex disorder involving the whole body and the diagnosis of depression is based on a heterogeneous set of symptoms. Objectives: To evaluate antidepressant activity of Areca catechu Ethanol Extract in Swiss Albino Mice. Materials and Methods: Adult Swiss albino mice were selected and randomly divided in to five groups as control which received normal saline, standard which received Imopramine 10mg/kg and

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... hree test groups which received Areca catechu ethanol extract at the dose of 40, 80 and 160 mg/kg respectively. All the drugs were administered intraperitonially (0.1ml/10gm) 30 minutes hour before the experiment followed by testing with forced swim test and tail suspension test successively to note the duration of immobility with the observation as mean± SD and was compared with the control by using ANOVA followed by Dunnets test. p<0.05 was considered as significant. Conclusion: We found that, acute treatment with Areca catechu ethanol extract at the dose of 80mg/kg and at the dose of 40 and 80mg/kg has shown significant antidepressant action by forced swim test and tail suspension test respectively.