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Associations of single nucleotide polymorphisms related to insulin resistance with polycystic ovary syndrome
Annals of Clinical and Laboratory Science
We investigated and validated most of the hitherto-suggested polymorphisms for PCOS. DNA samples from 359 pre-menopausal Korean women with PCOS (n=196) and without (n=166) were analyzed by primer extension and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry using iPLEX Gold technology from Sequenom (Sequenom Inc, San Diego, CA, USA) to determine the genotypic frequency of 80 single nucleotide polymorphisms (SNPs) from the 49 genes. Four SNPs (rs10060745,pmid:25117097 fatcat:xqthmo5winfpfhcixmdmkccsjm