The treatment of diabetes by duodenal preparations

Alfred R. Parsons
1908 Transactions of the Royal Academy of Medicine in Ireland  
The Pancreas and Diabetes.--In 1890 Minkowski and von Mering showed that in an animal complete removal of the pancreas produced the typical symptoms of diabetes. Subsequent observations proved that if one-fffth, or in some cases even one-tenth, of the gland be left untouched the animal does not become diabetic. I• was naturally suggested that the development of diabetes should be attributed to the grave injury inflicted on important nervous structures by the removal of ah organ occupying the
more » ... ition of the pancreas. Minkowski easily negar[red such a suggestion by showing that if the pancreas be removed from its normal site and be implanted on the anterior abdominal wall the animal does not become diabetic. There is abundant evidence clinical, pathological and experimental--to show that the symptoms cannot be attributed to the absence of the external secretion. The accepted though non-proven explanation of the development of diabetes under these conditions is that one function of the pancreas is to produce an internal secretion which plays an important part in the r£ of glycolysis. Lepine at first thought that the glycolytic process took place in the blood. This was d prior[ improbable, and Cohnheim's suggestion, that its site was in the tissues, has received considerable support Ÿ expe¡ made last year by E. W. Hall, who showed that an alcoholic extract of boiled pancreas added to muscle facilitated a combustion of sugar. The Source o] the Internal Pancreatic Secretion. Scattered I 130 The Treatment o] Diabetes.
doi:10.1007/bf03173056 fatcat:pa776ru6lzavffd6tj3jasvsqi