December (2013) Res

Manjula Arul, Antony, S Arul, Antony
Research Journal of Chemical Sciences   unpublished
The coordination compounds using Co(II), Ni(II), Cu(II) and Zn(II) ions with Schiff base ligand derived from furfurilydene-4-aminoantipyrine with o-anisidine in a 1:1 molar ratio have been synthesized and characterised by elemental analysis, IR, NMR and electronic spectral studies. On the basis of spectral studies, octahedral geometry is suggested for Co(II), Ni(II), Cu(II) and tetrahedral geometry for Zn(II) complexes. The synthesized ligand and metal(II) complexes have been tested against
more » ... tested against bacterial species Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and fungal species Aspergillus niger (A. niger), Aspergillus fumigatus (A. fumigatus) and Candida albicans (C. albicans) in order to assess their antimicrobial properties. The results show that the metal complexes were more active than the ligand. The DNA cleavage activity of the ligand and its complexes were assayed using PUCI8 DNA by gel electrophoresis. The result shows that complete cleavage of DNA was observed in Cu(II) and Zn(II) complexes and partial cleavage of DNA was observed in Co(II) and Ni((II) complexes.