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Dyspepsia is a common reason for the clinical encounters in primary care. Two common causes of dyspepsia are gastroesophageal reflux disease (GERD) and peptic ulcer disease (PUD). These diseases clinically overlap and may present diagnostic and management challenges in primary care, especially in low resource settings. Proton pump inhibitors, eradication of H. pylori infection and endoscopy form the backbone of management of both diseases. This article reviews current considerations in thedoi:10.4102/safp.v60i3.4876 fatcat:kwb3siklgzbczl3imo3vs3acz4