Potential application of Colonic drug delivery system in prevention and treatment of Colorectal Cancer

Mudassir Ansari, Kavita Singh
2021 The Journal of Pharmaceutical Sciences and Medicinal Research  
Colorectal cancer (CRC) is the second leading cause of cancer related deaths in USA. The current regimen used to treat colorectal cancer has many side effects and have higher drug distribution in other tissues. Physical activity and diet play major role in prevention of Colon cancer which is briefly discussed in this paper. Colon targeted drug delivery system (CoDDS) is found to be a promising approach to target the drug specifically to colon. This review provides the description of various
more » ... n targeted approaches that can be used to treat CRC. Factors to be consider while designing CoDDS include pH of GIT, Transit time of GI tract and Microbiota of colon. This review will discuss the staging and standard treatments modalities for CRC.
doi:10.53049/tjopam.2021.v001i03.011 fatcat:6pxe4j4xenggrpiandgrnpqate