P.052 BLOOD PRESSURE AND LARGE ARTERIAL ELASTIC PROPERTIES. BENEFIT OF BETAXOLOL IN HYPERTENSION

F.T. Ageev, Y.A.A. Orlova, B.D. Kulev, O.N. Baldina
2006 Artery Research  
Poster Presentations S39 waveform. We investigated this during cardiac catheterisation, examining the effects of pacing and nitroglycerin (NTG) on estimation of central systolic pressure from the peripheral pulse. Methods: Patients undergoing coronary angioplasty (n = 11, aged 48 to 72 years) participated. A Millar SPC-454D or fluid filled catheter was placed in the aortic root and a pacing wire in the right atrium. Peripheral digital arterial waveforms (Finometer) and aortic waveforms were
more » ... waveforms were obtained at baseline, during pacing at 20 bpm above resting heart rate and during administration of NTG (10 and 100 mg/min, i.v.). Results: Pacing and NTG produced marked changes in central and peripheral waveforms, reducing central augmentation index from 40.4±6.2 to 22.6±8.9% and from 40.4±6.2 to 12.7±7.0% for pacing and NTG 100 mg/min respectively (each P < 0.01). At baseline and during all interventions, there was a close correlation between central systolic blood pressure and absolute finger systolic pressure at the point of late systolic augmentation (R = 0.95, P < 0.0001). The mean difference between measured central aortic systolic BP and that estimated from digital pressure was 2.2 mmHg SD 6.2 mmHg. Conclusions: These data suggest that central systolic blood pressure can be estimated directly from non-invasive finger pressure waveforms even during interventions such as pacing and NTG that produce a marked change in pressure waveforms. P.049 Introduction: Exercise reduces systolic augmentation in the peripheral pulse wave, an effect similar to that produced by the nitric oxide (NO) donor nitroglycerin (NTG). The changes produced by exercise persist into the recovery period for >30 min. The aim of this study was to investigate if the exercise induced changes are dependent on endothelium-derived NO. We used the NO synthase inhibitor N G -monomethyl-L-arginine (L-NMMA) to test this. Methods: Healthy volunteers (n = 10, 5 female, aged 19 to 33 years) participated in a 2-phase randomised controlled cross-over study. L-NMMA (6 mg/kg i.v. over 5 min) and saline placebo were given immediately before exercise on two occasions separated by at least 5 days. Mean arterial blood pressure (MAP by Finopress), radial augmentation index (RAIx by SphgymoCor) and cardiac output (Innocor) measurements were made at baseline, during infusion of L-NMMA/saline immediately before exercise, during exercise (except for radial artery measurements) and during recovery. Peripheral vascular resistance (PVR) was calculated from MAP and cardiac output. During exercise, workload increased from 25 W to 150 W by increments of 25 W at 2 min intervals. Results: Before exercise, L-NMMA increased mean arterial blood pressure (85.1±3.8 vs. 101.2±4.3 mmHg, P < 0.01), peripheral vascular resistance (16.4±0.7 vs. 24.7±1.7 mmHg/ml/min, P < 0.01) and RAIx (50.2±4.5 vs. 70.2±6.5%, P < 0.01) and decreased heart rate (65.6±5.7 vs. 49.1±2.8 bpm, P < 0.01). During and after exercise, heart rate, MAP and PVR were similar after L-NMMA and saline. However, L-NMMA attenuated the exercise induced fall in RAIx so that RAIx was higher after L-NMMA compared to saline at 15 min in recovery (49.5±5.3 vs. 36.0±4.4%, P < 0.02). Conclusion: These data suggest that, although endothelium derived NO has little effect in regulating PVR during/after exercise, it may have a role in mediating exercise induced changes in the pulse waveform. P.050 THE INSULIN SENSITIZER ROSIGLITAZONE IMPROVES ENDOTHELIAL FUNCTION IN PATIENTS WITH TYPE 2 DIABETES ON INSULIN
doi:10.1016/s1872-9312(07)70075-3 fatcat:xfydl7be2vbprfetde5ci4qdlu