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Severe combined immunodeficiency pig as an emerging animal model for human diseases and regenerative medicines
Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell transplant. Functional NK cells may impact engraftment success of life-saving procedures such as bone marrow transplantation in human SCID patients. Therefore, in animal models, a Tdoi:10.5483/bmbrep.2019.52.11.267 fatcat:fjbeedfd3vemra6fn52y6tmkbe