A Multi-Objective Genetic Algorithm that Employs a Hybrid Approach for Isolating Codon Usage Bias Indicative of Translational Efficiency

Douglas W. Raiford, Dan E. Krane, Travis E. Doom, Michael L. Raymer
2007 2007 IEEE 7th International Symposium on BioInformatics and BioEngineering  
Isolation oftranslational efficiency bias can have important applications in gene expression prediction and heterologous protein production. In some genomes the presence of a high GC(AT)-content bias can confound the isolation of translational efficiency bias. In other organisms translational efficiency bias is weak making it difficult to isolate. Described here is a multi-objective genetic algorithm that improves the isolation of translational efficiency bias in Streptomyces coelicolor A3(2)
more » ... d Pseudomonas aeruginosa PAOI, two organisms shown to have high GC-content and weak translational efficiency bias.
doi:10.1109/bibe.2007.4375577 dblp:conf/bibe/RaifordKDR07 fatcat:yre4xfpn5naetgh2lwzfqcfzoe