ISYS: a decentralized, component-based approach to the integration of heterogeneous bioinformatics resources

A. Siepel, A. Farmer, A. Tolopko, M. Zhuang, P. Mendes, W. Beavis, B. Sobral
2001 Bioinformatics  
Motivation: Heterogeneity of databases and software resources continues to hamper the integration of biological information. Top-down solutions are not feasible for the full-scale problem of integration across biological species and data types. Bottom-up solutions so far have not integrated, in a maximally flexible way, dynamic and interactive graphical-user-interface components with data repositories and analysis tools. Results: We present a component-based approach that relies on a
more » ... platform for component integration. The platform enables independently-developed components to synchronize their behavior and exchange services, without direct knowledge of one another. An interface-based data model allows the exchange of information with minimal component interdependency. From these interactions an integrated system results, which we call ISYS T M . By allowing services to be discovered dynamically based on selected objects, ISYS encourages a kind of exploratory navigation that we believe to be well-suited for applications in genomic research. Availability: A 'developer's kit' for creating software that uses the ISYS platform is available at research/isys/devrel.html. It includes a more refined and fully documented version of the platform and a starting set of ISYS-ready components. Up-to-date descriptions of the ISYS project can be found at Contact:
doi:10.1093/bioinformatics/17.1.83 pmid:11222265 fatcat:yiqxnsvsazh3zeksbvxttfk2di