Body Mass Index and the Risk of Stroke in Men

Tobias Kurth, J. Michael Gaziano, Klaus Berger, Carlos S. Kase, Kathryn M. Rexrode, Nancy R. Cook, Julie E. Buring, JoAnn E. Manson
2002 Archives of Internal Medicine  
Although obesity is an established risk factor for coronary heart disease, its role as a risk factor for stroke remains controversial. Methods: Prospective cohort study among 21414 US male physicians participating in the Physicians' Health Study. Incidence of total, ischemic, and hemorrhagic stroke was measured by self-report and confirmed by medical record review. We used Cox proportional hazards models to evaluate the association of body mass index (BMI), calculated as self-reported weight in
more » ... -reported weight in kilograms divided by the square of the height in meters, with risk of total, ischemic, and hemorrhagic stroke. Results: During 12.5 years of follow-up, 747 strokes (631 ischemic, 104 hemorrhagic, and 12 undefined) occurred. Compared with participants with BMIs less than 23, those with BMIs of 30 or greater had an adjusted relative risk of 2.00 (95% confidence interval [CI], 1.48-2.71) for total stroke, 1.95 (95% CI, 1.39-2.72) for is- METHODS Participants were part of the PHS, a completed randomized trial of low-dose aspirin and beta carotene in the primary prevention of cardio- ORIGINAL INVESTIGATION
doi:10.1001/archinte.162.22.2557 pmid:12456227 fatcat:ct7tgh6effc7hjwkqo7lo5rfgq