Department of Chemistry, Dr. H. S. Gour University, Sagar-470 003, Madhya Pradesh, India E-mail: ratnesh_das@rediffmail.com Manuscript received 7 September 2004, revised 10 May 2005, accepted 30 December 2005 Physicochemical and microbial studies on CoII-ascorbic acid complex have been done in solid and aqueous phase. On the basis of elemental analysis, polarographic studies and amperometric titrations, the metal : drug ratio has been worked out to be 1 : 1. IR spectral studies have been used

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... ascertain metal : ligand binding site. Microbial studies on the complex was done against various pathogenic barteria viz. Eschirichia coli, Salmonella typhi, Vibrio cholerae and Diploccocus pneumoniae. The results of the microbial studies with the metal : drug complex revealed that the drug : metal complex is more potent against the pathogenic bacteria as compared to the pure drug, ascorbic acid.