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Investigation of 5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione as a Matrix for Analyses of Biogenic Monoamine Transmitters Using MALDI-MS

Hiroko KASAI, Masamichi NAKAKOSHI, Tomomi SUGITA, Mayu MATSUOKA, Yuzo YAMAZAKI, Yumi UNNO, Hiroki NAKAJIMA, Hideshi FUJIWAKE, Masayoshi TSUBUKI
2016 Analytical Sciences  

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In order to discover new matrices suitable for the analyses of low molecular-weight compounds using positive-ion mode matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry (MS), 5-(3-trifluoromethylbenzylidene)thiazolidine-2,4-dione (3-CF3-BTD) was synthesized, and its effectiveness was compared with that when commercially available α-cyano-4-hydroxycinnamic acid was used. 3-CF3-BTD was sufficiently sensitive to analyze neurotransmitters, i.e., dopamine,
more » ... histamine, and epinephrine, in amounts of several picomoles. Similar to vacuum MALDI experiments, atmospheric-pressure MALDI-MS measurements using 3-CF3-BTD as a matrix also detected dopamine.
doi:10.2116/analsci.32.907 pmid:27506719 fatcat:hstreu7n5je5vfneqjx5v6egmq
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Hiroko KASAI, Masamichi NAKAKOSHI, Tomomi SUGITA, Mayu MATSUOKA, Yuzo YAMAZAKI, Yumi UNNO, Hiroki NAKAJIMA, Hideshi FUJIWAKE, Masayoshi TSUBUKI. "Investigation of 5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione as a Matrix for Analyses of Biogenic Monoamine Transmitters Using MALDI-MS." Analytical Sciences 32.8 (2016) 907-910